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Strategies to Assist Patient with Smoking Cessation
by James O’Keefe, Jr,
MD (Director of Preventive Medicine, Mid-America Heart Institute, Kansas
City, MO), Mark S. Freed, MD (Cardiologist, President of Physicians'
Press), and Christie Ballantyne, MD (Clinical Director, Section of
Atherosclerosis, Baylor College of Medicine)
Overview
Smoking
tobacco is the most preventable cause of death in the United States.
Each year, 400,000 deaths are attributable to tobacco use, more than
alcohol abuse, automobile accidents, AIDS, homicide, suicide, heroin,
and cocaine combined! Compared to age-matched nonsmokers, persons
who smoke one pack of cigarettes per day are 14 times as likely to die
from cancer of the lung, throat or mouth; four times as likely to die
from cancer of the esophagus; and twice as likely to die from heart
disease or cancer of the bladder. At any age, the risk of death is
doubled in smokers compared with nonsmoking age-matched controls. In
addition to the risk of premature death, millions of smokers suffer
chronic disability from tobacco-related illnesses, including heart
attack, stroke, claudication, and emphysema. Infants of mothers who
smoke during and after pregnancy are three times more likely to die from
sudden infant death syndrome, and children of smokers have an increased
risk of ear infections, pneumonia, bronchitis and tonsillitis, and are
more likely to become smokers themselves. Despite these statistics, few
physicians routinely ask patients about cigarette smoking or offer
counseling about smoking cessation. The risk of coronary artery disease
attributable to smoking returns to baseline soon after cessation of
tobacco use. By 12-18 months, most of the increase in risk has
disappeared; by 3-5 years, the risk of coronary events is no different
than that of a nonsmoker. As a physician, there is virtually nothing
more effective at improving a patient’s long-term prognosis than
convincing and helping him or her to stop smoking. If a physician
discusses this topic—even briefly—with the smoker and makes a strong
statement about the medical necessity of discontinuing this habit, a
person’s chances of permanent cessation of smoking is doubled!
The use of bupropion hydrochloride (Zyban) and nicotine replacement
therapy (NRT) also increase the chances of successful smoking cessation.
Guidelines
The U. S. Public
Health Service recently issued clinical practice guidelines for treating
tobacco use and dependence (JAMA 2000;283:3224), recognizing that more
than 70% of smokers visit a health care setting each year, and that most
smoker want to quit completely. Guidelines were based on 6000
peer-reviewed articles and abstracts, then generated by a panel of 18
members and submitted for external review and revision by more than 70
experts. They concluded that every patient should be asked about
cigarette smoking at every visit, that smokers should be strongly
encouraged to stop, and that NRT and/or bupropion hydrochloride should
be offered to all smokers. In their report, the Expert Panel from
the U.S. Public Health Service recommended the following strategies to
help patients willing to quit smoking:
Step 1:
Systematically identify all tobacco users at every visit.
Place tobacco-use status stickers on all patient charts.
Step 2:
Strongly urge all tobacco users to quit.
Advice should be clear, strong, and personalized: "I think it is
important for you to quit smoking now, and I can help you."
"As your clinician, I need you to know that quitting smoking is the
most important thing you can do to protect your health now and in the
future. The clinic staff and I will help you." Tie tobacco use to
current health/illness, its social and economic costs, motivation
level/readiness to quit, and its impact on children and others in the
household.
Step 3:
Determine willingness to make a quit attempt.
If the patient is willing to make a quit attempt at this time, assist
the patient in quitting (Table 1) or refer to a quit-smoking program. If
the patient is unwilling to make a quit attempt, provide a motivational
intervention.
Step 4: Aid
the patient in quitting
(Tables 1-2).
Step 5:
Schedule follow-up contact.
Follow-up contact should occur soon after the quit date, preferably
during the first week. A second follow-up contact is recommended within
the first month. Schedule further follow-up contacts as indicated.
Congratulate success during follow-up contact. If tobacco use has
occurred, review circumstances and elicit recommitment to total
abstinence. Remind patient that a lapse can be used as a learning
experience. Identify problems already encountered and anticipate
challenges in the immediate future. Assess pharmacotherapy use and
problems. Consider use or referral to more intensive treatment.
For patients who
continue smoking, it is important to appreciate clinically significant
interactions between cardiovascular drug therapy and cigarette smoking.
These include anticoagulants (increased elimination; may require higher
dose of anticoagulant), beta-blockers (increased hepatic metabolism; may
require higher dose of beta-blocker), and diuretics (possible increased
secretion of vasopressin and decreased diuretic effect).
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Table
1. Strategies to Assist Patients Willing to Quit Smoking |
|
Step |
Strategies
for Implementation |
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Help
the patient with a quit plan |
Set
a quit date. Tell family, friends, and coworkers about
quitting; request understanding and support. Anticipate
withdrawal symptoms and how to resist urges and cravings (clean
the house; take a 5-minute walk; do stretching exercises; call a
nonsmoking friend and talk). Throw out ashtrays; clean
clothes and car. Learn as much about how to quit smoking as
possible. Useful sources for reading materials include the
American Heart Association (7272 Greenville Avenue, Dallas, TX
75231, 800-242-8721), American Cancer Society (1599 Clifton Road,
NE, Atlanta, GA 30329, 800-227-2345), American Lung Association
(1740 Broadway, 14th floor, New York, NY 10019, 800-586-4872) |
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Provide
practical counseling |
Total
abstinence is essential: "Not even a single puff after the
quit date." Identify what helped and what hurt in
previous quit attempts. Discuss challenges/triggers and how
to overcome them successfully. Since alcohol can cause
relapse, the patient should abstain from alcohol while quitting.
Patients should encourage housemates to quit with them or not to
smoke in their presence. Provide a supportive clinical
environment while encouraging the patient during the quit attempt:
"My office staff and I are available to assist you" |
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Recommend
the use of approved pharmacotherapy (Table 2)
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Bupropion
may be more effective than NRT for achieving permanent cessation
of tobacco use, but there are insufficient data to rank-order
first-line therapies. Some synergy between the two approaches may
exist. Sustained-release bupropion and nortriptyline are
well-suited for patients with a history of depression.
Combining the nicotine patch with either nicotine gum or nicotine
nasal spray may increase long-term abstinence rates compared to
single-NRT treatment. The nicotine patch in particular is
safe in patients with cardiovascular disease and has been shown
not to cause adverse cardiovascular effects. However, the safety
of these products has not been established for the immediate
post-MI period or in patients with unstable angina.
Long-term therapy may be helpful for smokers who report persistent
withdrawal symptoms |
| Abbreviations:
MI = myocardial infarction; NRT = nicotine replacement therapy.
Adapted from: The U.S. Public Health Service Clinical Practice
Guidelines for Treating Tobacco Use and Dependence (JAMA
2000;283:3224) |
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Table
2. Drug Therapy for Smoking Cessation* |
|
Pharmacotherapy |
Precautions/
Contraindications |
Adverse
Effects |
Dosage
and Duration |
|
First-line
Bupropion HCl (Zyban®) |
History
of seizures or eating disorder |
Insomnia;
dry mouth |
150
mg every morning for 3 days then 150 mg twice daily (begin
treatment 1-2 weeks prior to quit). Treat for 7-12 weeks;
maintenance up to 6 months |
|
Nicotine
gum |
Concurrent
cigarette smoking is contraindicated due to the risk of nicotine
overdose |
Mouth
soreness; dyspepsia |
1-24
cigarettes/d: 2 mg
gum (up to 24 pieces/d); > 25 cigarettes/d:
4 mg gum (up to 24 pieces/d). Treat up to 12 weeks |
|
Nicotine
inhaler |
Concurrent
cigarette smoking is contraindicated due to the risk of nicotine
overdose |
Local
irritation of mouth and throat |
6-16
cartridges/d for up to 6 months |
|
Nicotine
nasal spray |
Concurrent
cigarette smoking is contraindicated due to the risk of nicotine
overdose |
Nasal
irritation |
8-40
doses/d for 3-6 months |
|
Nicotine
patch |
Concurrent
cigarette smoking is contraindicated due to the risk of nicotine
overdose |
Local
skin reaction; insomnia |
21
mg/24 h (4 weeks), then 14 mg/24 h (2 weeks), then 7 mg/24 h (2
weeks). Alternative: 15 mg/16 h (8 weeks) |
|
Second-line
Clonidine |
Rebound
hypertension |
Dry
mouth; drowsiness; dizziness; sedation |
0.15-0.75
mg/d for 3-10 weeks |
|
Nortriptyline |
Risk
of arrhythmias |
Sedation;
dry mouth |
75-100
mg/d for 12 weeks |
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*
The information contained in this table is not comprehensive.
First-line pharmacotherapies have been approved for smoking
cessation by the Food and Drug Administration; second-line agents
have not. From: The U.S. Public Health Service Clinical Practice
Guidelines for Treating Tobacco Use and Dependence (JAMA
2000;283:3224). |
© 2009 Jones and Bartlett Publishers
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