Science in Medicine goes beyond introductory textbooks of basic clinical medicine to present a more sophisticated, in-depth, and multi-layered view of known mechanisms of disease in print and electronic format.

The text examines our understanding of disease mechanisms for an array of over 140 diseases and disorders affecting all major organ systems.

Written with the general, non-specialist JCI readership in mind, the text is broad and all-inclusive, outlining the fundamentals of the organ or other physiologic systems in question and proceeding to examine the underlying genetic of physiological abnormalities that result in disease.  In cases where significant therapeutic advances have been made that are currently available in the clinic or in clinical trials, the fundamentals of drug action are examined in greater detail.

The text incorporates an explosion of new topics relevant to global public health such as the SARS virus, improved anthrax vaccines, and science, policy, and ethics of stem cell use.

Individual reviews are concise, accessible, and most often written as a self-contained treatment and focus on biological findings that are relevant to standard or experimental clinical practice.